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Introduction

Chapter 10 discusses compounds, other than alkyl halides, that undergo substitution and/or elimination reactions. Because alcohols and ethers have relatively poor leaving groups compared with the leaving groups of alkyl halides, alcohols and ethers must be activated before the groups will leave.

Several methods commonly used to activate leaving groups are examined. Other compounds that undergo substitution and/or elimination reactions, such as epoxides, are also discussed. Amines are one group of compounds that will not undergo substitution or elimination reactions, and this chapter explains why.

We will also look at arene oxides in this chapter. It has long been known that certain arene oxides are carcinogenic. Here you see why this is so, and you learn how to predict from their structures the ones that are most apt to cause cancer.




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