| |
Regulation of Gene Expression
Web Resources
|
- Micro 316 Microbial Genetics
- Notes from a course on Microbial Genetics by Dr. Stanley Maloy at the University of Illinois. The site is well designed and presented. Most of the site is in outline form but some useful graphics are included. (http://www.life.uiuc.edu/micro/316/supplement.html)
- Induction of the lac operon
- Gene transcription can be switched on and off by gene regulation proteins. The lac operon in E.coli is an example of that dual control. Glucose and lactose levels control the initiation of transcription of the lac operon, i.e., whether the lac operon is switched "ON" or "OFF". (http://www.accessexcellence.org/AB/GG/induction.html)
- The Lac Operon
- Jacob and Monod were the first scientists to elucidate a transcriptionally regulated system. They worked on the lactose metabolism system in E. coli. (http://esg-www.mit.edu:8001/esgbio/pge/pgeother.html)
- Regulation and Control of Metabolic Activities
- Unlike plant and animal cells, most bacteria are exposed to a constantly changing physical and chemical environment. Within limits, bacteria can react to changes in their environment through changes in patterns of structural proteins, transport proteins, toxins, enzymes, etc., which adapt them to a particular ecological situation. (http://www.bact.wisc.edu/Bact303/Regulation)
- Control of Gene Expression
- The controls that act on gene expression (i.e., the ability of a gene to produce a biologically active protein) are much more complex in eukaryotes than in prokaryotes. A major difference is the presence in eukaryotes of a nuclear membrane, which prevents the simultaneous transcription and translation that occurs in prokaryotes. Whereas in prokaryotes, control of transcriptional initiation is the major point of regulation, in eukaryotes the regulation of gene expression is controlled nearly equivalently from many different points. (http://www-isu.indstate.edu/thcme/mwking/gene-regulation.html)
|
