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Translation and Proteins
Web Resources
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Crystallographic analysis has revealed many details about the functional prokaryotic ribosome.
- Imaging the ribosome
(http://www.accessexcellence.org/WN/SUA13/ribo999.html) This site discusses the X-ray structure of the ribosome and the implications.
The initial insight that proteins are important in heredity was provided by the study of inborn errors of metabolism.
- Online Mendelian Inheritance in Man-Phenylketonuria
This is the Online Mendelian Inheritance in Man entry for phenylketonuria (http://www.ncbi.nih.gov/entrez/dispomim.cgi?id=261600). You can learn about clinical features and management, population genetics, molecular genetics, evolution, and many other topics.
Studies of human hemoglobin established that one gene encodes one polypeptide.
- Joint Center for Sickle Cell and Thalassemia Disorders
(http://sickle.bwh.harvard.edu) Take a visit to the Joint Center for Sickle Cell and Thalassemia Disorders at Brigham and Women's Hospital and Massachusetts General Hospital. General information on sickle-cell disease and thalassemias is available at this site.
- Online Mendelian Inheritance in Man-Sickle Cell Anemia
(http://www.ncbi.nih.gov/entrez/dispomim.cgi?id=603903) The Online Mendelian Inheritance in Man entry for sickle-cell anemia is available at this location. Extensive information on the genetics of sickle-cell, allelic variants, clinical features and references to the primary literature. A wealth of information is available at this site for other hemoglobin disorders.
Protein function is directly related to the structure of the molecule.
- Prion Diseases
Extensive information on prion diseases of both humans and other animals is provided at this location. Topics presented include the similarities and differences among human prion diseases, evidence for and against the protein only model of infection, how these proteins might be infectious and others. Additional links to other sites are found at the end of the page.
- Protein Design
The homepage of the Protein Design Group of the National Center for Biotechnology of the Spanish Research Council. Their interests range from protein design to protein folding and function. This site includes references to the primary literature.
- Centre for Protein Engineering
The homepage of the Centre for Protein Engineering in Cambridge, UK contains the program "scop," which contains a database based on the structural classification of proteins, as well as information about ongoing research, the research personnel and their publications.
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