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Chapter 5: Mendelian Genetics in Populations I: Selection and Mutation Destinations

Explore key concepts and research through these links to additional web resources.

5.1 Mendelian Genetics in Populations: The Hardy-Weinberg Equilibrium Principle

• Hardy-Weinberg Principle
  The Woodrow Wilson Leadership Program in Biology offers this site for K-12 teachers. It includes the kinds of questions an instructor might encounter in teaching this topic. Materials are provided to explaining the Hardy-Weinberg principles, as well as written materials providing background information and lesson plans.
  Keywords: Hardy-Weinberg, alleles, frequency

• On-line Mendelian Inheritance in Man
  From the National Center for Biotechnology Information, the On-line Mendelian Inheritance in Man (OMIM) site allows users to search for information on a variety of Mendelian traits, including loss-of-function genetic diseases. The site links users to information on clinical manifestations, genetic information, mapping information, and more.
  Keywords: OMIM, Mendelian traits, genetic diseases

5.2 Selection

• Scale-eating Cichlids
  This short essay describes some of the fascinating feeding adaptations of cichlid fish and a discussion of Hori's work on frequency-dependent selection on scale-eating fish.
  Keywords: scale-eating fish, selection, genetic frequency

• Hardy-Weinberg Equilibrium According to Hoyle
  Access Excellence offers this site - "Hardy Weinberg According to Hoyle," another resource for K-12 teachers interested in using playing cards to simulate and teach Hardy-Weinberg principles.
  Keywords: Hardy-Weinberg Equilibrium, simulations, frequencies

5.3 Patterns of Selection: Testing predictions of population genetic theory

• Population Biology Simulations
  Here is an interesting site with many simulations designed to enhance your understanding of the dynamics of population genetics. Visit the Genetic Drift link to see how allele frequencies change over time as a result of genetic drift in small populations.
  Keywords: population biology, genetic drift, simulations

• Buck vs. Bell and Sterilization
  This article from the Dolan DNA Learning Center at Cold Spring Harbor Laboratory highlights the current genetic thinking of the time. Here you can learn about how the eugenicist's movement in American resulted in a policy of sterilization in an uninformed attempt to control the genetics of the US population.
  Keywords: Cold Spring Harbor, population genetics, sterilization

5.4 Mutation

• Cystic Fibrosis Center
  Cystic Fibrosis is one of the most common genetic diseases in the United States. The website for The Cystic Fibrosis Center at Stanford University is a good comprehensive site about this disease.
  Keywords: cystic fibrosis, genetic disease, gene therapy

• Engines of Evolution
  This article from Natural History Magazine discusses evolutionary change and its driving force. Here you can read a little about some of the current studies underway to investigate this 'change' in a variety of systems.
  Keywords: mutation, selection, evolutionary change