1.
Suppose that during a detailed anatomical study of a marine invertebrate, you found a small, previously undescribed structure. How would you test the hypothesis that the structure is a gland that releases one or more hormones?
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2.
Cortisone is a glucocorticoid that suppresses inflammation and other aspects of wound healing. Cortisone was once widely used to treat athletes with joint injuries and people who suffered from arthritis. Short-term, it is extremely effective in reducing swelling and pain. Over time, however, physicians found that repeated large doses of cortisone had damaging side effects. Predict what these side effects are. Explain your logic.
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3.
You are a physician supervising a patient's recovery from surgical removal of the posterior pituitary. Name a hormone that you will have to administer to this patient artificially. Which symptom(s) will you monitor to assess whether the dosage and timing of your injections is having the desired effect?
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4.
Suppose that a researcher announces the discovery of a hormone that affects the metabolism of fats in lab rats. Preliminary data indicate that the hormone is a polypeptide, about 50 amino acids long. How would you go about isolating the receptor for this hormone? Using fat cells growing in vitro, how could you test the hypothesis that hormone binding causes a change in a second messenger?
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5.
Discuss the trade-offs involved in the short-term response to stress in humans. What are the advantages and disadvantages of activating certain systems in the body while shutting others down?
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6.
Study Figure 44.4 (page 855 in your textbook) and note that the components of the endocrine system are all located along the midline of the body. Suggest a hypothesis for why this pattern exists.
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7.
Turn back to Chapter 14 and briefly review the role of cAMP in the regulation of the lac operon in Escherichia col i . How does cAMP's role in glucose utilization by bacteria compare to the role of cAMP in the production of glucose by human cells in response to epinephrine?
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