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| 1. |
Sickle-cell disease is a recessive genetic disorder in which hemoglobin is improperly synthesized. If you were searching for the gene involved in this disorder, which of the following would be the first step?
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| 2. |
If you have created a cDNA library of mRNA produced by a given cell type, what is the optimal next step in producing large numbers of the cDNA molecules that are coded for by each different mRNA?
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| 3. |
If you were the experimenter conducting this experiment, and you have isolated an E. coli colony that contains the growth hormone gene, what would be the best next step?
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| 4. |
If you were examining a group of individuals who were color-blind (an X-linked recessive trait where retinal cells do not detect all of the colors), which of the following would be most helpful in initial studies that are focused on finding the gene?
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| 5. |
What type of inheritance pattern is depicted in this pedigree?
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| 6. |
If a trait is autosomal, recessive
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| 7. |
If the individual on the bottom left of this pedigree (the purple square closest to the IV) were to marry a phenotypically normal woman (as shown in the diagram), which of the following best describes the occurrence of Huntington’s disease in their children?
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| 8. |
Which of the following is NOT one of the results that came from determining the sequence of the Huntington’s gene?
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| 9. |
If a child has cystic fibrosis, a genetic disorder that affects the lungs, which of the following would be the best "gene therapy" for the child?
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| 10. |
Which of the following statements is true?
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| 11. |
Genetic engineering became possible after the discovery of which of the following compounds?
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| 12. |
Which of the following was the primary reason that it was necessary to develop a method of using recombinant DNA technology to produce human growth hormone for treatment of individuals with pituitary dwarfism?
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| 13. |
Some proteins require extensive post-translational modification, which primarily occurs in the Golgi apparatus of the cell. Which of these cell types would be the best to use, if you wished to use plasmid-based recombinant DNA technology to produce a human protein that required post-translational modification?
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| 14. |
Refer to Figure 17.1 on page 337 of your textbook. The plasmid used in this experiment must include which of the following, before being inserted into E. coli cells?
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| 15. |
Refer to Figure 17.2 on page 338 of your textbook. Which of the following would be the most likely result if step 3 of the procedure were omitted?
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| 16. |
Restriction enzymes are formed in bacteria to break down viral DNA. When restriction sites are placed on a human gene, and human DNA and viral DNA with the same restriction site are cut with the restriction enzyme, the “sticky ends” of the two can recombine, and the virus may be used to incorporate the gene into a human chromosome. Pick the statement that best describes the paragraph above.
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| 17. |
How is the pedigree of an individual generally constructed? 
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| 18. |
Which of the following is true regarding the trait shown in this pedigree? 
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| 19. |
This figure demonstrates the inheritance of a genetic marker, in comparison to the inheritance of Huntington’s disease. What is the most likely reason that the boxes and circles are present, but the genetic marker information (the A, B, C, D patterns) is missing for so many of these individuals? 
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| 20. |
Which of the following is a disadvantage of using biotechnological techniques in agriculture?
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Answer choices in this exercise are randomized and will appear in a different order each time the page is loaded.
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