1.
Explain how open reading frames are identified in the genomes of bacteria and archaea. Why is it more difficult to find open reading frames in eukaryotes?
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2.
Why is the observation that parasitic organisms tend to have relatively small genomes logical?
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3.
How does a LINE sequence transmit a copy of itself to a new location in the genome? Why are LINEs and other repeated sequences referred to as "genomic parasites?"
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4.
How does DNA fingerprinting work? Stated another way, how does variation in the size of microsatellite and minisatellite loci allow investigators to identify individuals?
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5.
Researchers can create microarrays of short, single-stranded DNAs that represent many or all of the exons in a genome. Explain how these microarrays are used to (a) test the hypothesis that alternative splicing is common, and (b) document changes in the transcription of genes over time or in response to environmental challenges.
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