1.
Name some attributes of a model organism. In what sense are garden peas or fruit flies a "model?"
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2.
Why is the allele for wrinkled seed shape in garden peas considered recessive?
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3.
The alleles found in haploid organisms cannot be dominant or recessive. Why?
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4.
Biologists no longer use the term pure line except in a historical context. Instead, they simply refer to "pure-line" individuals as homozygotes. Explain.
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5.
The genes for the traits that Mendel worked with are either located on different chromosomes or are so far apart on the same chromosome that crossing over almost always occurs between them. How did this circumstance help Mendel recognize the principle of independent assortment?
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6.
The text claims that Mendel worked with the simplest possible genetic system. Do you agree with this statement? Why or why not?
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7.
The artificial sweetener NutraSweet(tm) consists of a Phenylalanine molecule linked to aspartic acid. The labels of diet sodas that contain NutraSweet include a warning to people with PKU. Why? Make a general comment on how aspects of an individuals environment affect the individuals phenotype using an example other than PKU.
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8.
When Sutton and Boveri published the chromosome theory of inheritance, research on meiosis had not yet established that paternal and maternal homologs actually do assort independently. Then in 1913, Elinor Carothers published a paper about a grasshopper species with an unusual karyotype. One chromosome had no homolog (meaning no pairing partner at meiosis I). Another chromosome had homologs that could be distinguished under the light microscope. If chromosomes assort independently, how often should Carothers have observed each of the four products of meiosis shown in the figure? Explain. of the alleles responsible for the spotted and unspotted phenotypes? Of orange and yellow? What can you conclude about the genotype of the original plant that had orange, spotted flowers?
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9.
In humans, the ABO blood type is a polymorphic trait. Describe the alleles and genotypes responsible for the polymorphism. Suppose a woman with blood type O married a man with blood type AB. What phenotypes and genotypes would you expect to observe in their offspring, and in what proportions?
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10.
A plant with orange-spotted flowers was grown in the greenhouse from a seed collected in the wild. The plant was self-pollinated and gave rise to the following progeny: 88 orange with spots, 34 yellow with spots, 32 orange with no spots, and 8 yellow with no spots. What can you conclude about the dominance relationships
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11.
As a genetic counselor, you routinely advise couples about the possibility of genetic disease in their offspring based on their family histories. This morning you met with an engaged couple, both of whom are phenotypically normal. The man, however, has a brother who died of Duchenne-type muscular dystrophy. This is an X-linked condition that results in death before the age of 20. The allele responsible for the disease is recessive. His prospective bride, whose family has no history of the disease, is worried that the couples sons or daughters might be afflicted.
12.
Study the experiment illustrated in Figure 10.8 and 10.9. To further test his hypothesis of independent assortment, Mendel let the F2 progeny from this experiment self-fertilize. Then he examined the phenotypes of the F3 generation.
13.
Suppose that you are heterozygous for two genes that are located on different chromosomes. You carry alleles A and a for one gene and alleles B and b for the other. Draw a diagram that illustrates what happens to these genes and alleles when meiosis occurs in your reproductive tissues. Label the stages of meiosis, the homologous chromosomes, sister chromatids, non-homologous chromosomes, genes, and alleles. Be sure to list all of the genetically different gametes that could form and how frequently each type should be observed. On the diagram, identify the events responsible for the principle of segregation and the principle of independent assortment.
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14.
Mr. Spock was the first officer of the starship Enterprise in the 1970s-era TV series called Star Trek. Mr. Spocks father came from the planet Vulcan and his mother from planet Earth. A Vulcan has pointed ears and a heart located on the right side of the chest. Mr. Spock has both of these traits, which are known to be determined by two different genes, with two alleles each. Suppose that Mr. Spock married an Earth woman and that they had many children. About half of their children look like Spock (pointed ears and right-sided heart) and about half look like their mother (rounded ears and left-sided heart).
15.
In the television program Star Trek, a group of human-like organisms called Klingons are the archenemies of the Enterprise crew. In Klingons, one gene determines hair texture while another determines whether the individual will have a saggital crest (a protrusion on the forehead). The two genes are not linked.
K = curly klingon hair (dominant)
k = silky earthling-like hair (recessive)
S = large saggital crest (dominant)
s = smooth, flat earthling-like forehead (recessive)
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