1.
Explain the lock-and-key model for enzyme activity. Be sure to comment on what the active site of an enzyme does.
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2.
Isoleucine, valine, leucine, phenylalanine, and methionine are amino acids with highly hydrophobic side chains. Suppose a section of a protein contained a long series of these hydrophobic residues. How would you expect this portion of the protein to behave when the molecule is in aqueous solution?
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3.
Explain how complementary base pairing makes the copying of RNA and DNA molecules possible. Your answer should include diagrams.
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4.
Turn back to Figure 3.8, which shows a generalized cartoon of monomers undergoing condensation reactions to form a polymer. Label the type of bond formed when amino acids polymerize to a polypeptide. Label the type of bond formed when nucleic acids polymerize to form RNA or DNA. Does it take energy for polymerization reactions to proceed, or do they occur spontaneously? Why or why not?
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5.
A major theme in this chapter is that the structure of molecules correlates with their function. Explain why DNAs secondary structure limits its catalytic abilities compared to RNA. Why are proteins the most effective catalysts of all?
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