Chapter 5: ActivitiesActivity 5.1 Transport into the Nucleus |
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How does a newly made protein find
its cellular destination, such as the nucleus? A protein destined for the nucleus contains a
kind of address label, called a nuclear localization signal (NLS). Proteins with NLSs bind
to nuclear receptors, which carry them through the nuclear pore complex and release
them inside the nucleus. In this activity, you'll see the types of experiments that clarified
why some proteins enter the nucleus and others do not. These experiments are modeled
on experiments performed by Carl Feldherr in the 1960s and by Colin Dingwall, Ronald
Laskey, and colleagues in the 1980s.
Transport of Small
versus Large Proteins Chapter 5, Section 5.2, The Nucleus and Nuclear Transport |