AVAILABILITY 13.9% cream

ACTIONS/THERAPEUTIC EFFECTS Topical eflornithine inhibits enzyme activity in the skin that is required for hair growth. It results in retarding the rate of hair growth.

PHARMACOKINETICS Absorption: <1% absorbed through intact skin. Metabolism: Not metabolized. Elimination: Excreted primarily in urine. Half-Life: 8 h.

USES Reduction of unwanted facial hair in women.

ROUTE & DOSAGE
Hair Removal
Adult: Topical Apply thin layer to affected areas of the face and adjacent involved areas under the chin and rub in thoroughly b.i.d. at least 8 h apart

ADMINISTRATION
Topical

• Apply thin layer to affected skin areas on face and under chin and rub in thoroughly.
• Do not wash treated areas for at least 4 h after application.
• Store at room temperature, 15°-30° C (59°-86° F).

CONTRAINDICATIONS Hypersensitivity to eflornithine or its components; lactation, children <12y.

PRECAUTIONS Pregnancy (category C).

ADVERSE EFFECTS Body as Whole: Facial edema. CNS: Dizziness. GI: Dyspepsia, anorexia. Skin: Acne, pseudofolliculitis barbae, stinging, burning, pruritus, erythema, tingling, irritation, rash, alopecia, folliculitis, ingrown hair.

NURSING IMPLICATIONS
Assessment & Drug Effects

• Monitor for and report skin irritation.
• Note: Drug slows growth of facial hair, but is not a depilatory.

Patient & Family Education

• Follow directions (see ADMINISTRATION).
• Note: Effect of drug is usually not apparent for 4-8 wks.
• Reduce frequency of drug application to once daily if skin irritation occurs. If irritation continues, contact physician.
• Do not breast feed while taking this drug.

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