Objectives

After reading this chapter, the student should be able to:

1. Identify common signs and symptoms of inflammation.
2. Outline the basic steps in the acute inflammatory response.
3. Describe the central role of histamine in inflammation.
4. Compare and contrast the humoral and cell-mediated immune responses.
5. Differentiate between H₁- and H₂-histamine receptors.
6. Describe common causes and symptoms of allergic rhinitis.
7. For each of the following classes, identify representative drugs, explain the mechanisms of drug action, primary actions related to inflammation and/or the immune system, and important adverse effects:
   1. H₁-receptor blockers
   2. Nonsteroidal anti-inflammatory drugs
   3. Intranasal and systemic glucocorticoids
   4. Intranasal and oral sympathomimetics
   5. Immunosuppressants
   6. Vaccines
   7. Biologic response modifiers
8. Categorize drugs used in the treatment of inflammation, allergies, and immune disorders based on their classifications and mechanisms of action.
9. For each of the major vaccines, give the recommended dosage schedule.